Home Ahead of print Instructions
About us Current issue Subscribe
Editorial board Archives Contact us
Search Submit article Login 
Print this page Email this page
ORIGINAL ARTICLE
Year : 2021  |  Volume : 18  |  Issue : 2  |  Page : 145-152

Impact of self-reported family history on some metabolic markers of type 2 diabetic patients


1 Department of Internal Medicine, Rasheed Shekoni Specialist Hospital, Dutse, Jigawa State, Nigeria
2 Department of Medical Laboratory Science, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria
3 Department of Chemical Pathology, College of Health Sciences, Nnamdi Azikwe University, Nnewi, Nigeria
4 Department of Chemical Pathology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria
5 Department of Medicine, Federal Medical Centre, Gusau, Zamfara State, Nigeria
6 Department of Physiotherapy, Dutse General Hospital, Dutse, Jigawa State, Nigeria
7 Department of Medical Laboratory Sciences, College of Health Sciences, Bayero University, Kano, Nigeria

Correspondence Address:
Dr. Salisu Babura Muazu
Department of Internal Medicine, Rasheed Shekoni Specialist Hospital, Dutse, Jigawa State
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/njbcs.njbcs_4_21

Rights and Permissions

Context: Family history of type 2 diabetes mellitus (T2DM), hypertension (HTN) and obesity, are known non-modifiable, independent and easily assessed risk factors for incident type 2 diabetes. Aims: This study was aimed at assessing the effect of self-reported family history on the levels of some metabolic markers (total homocysteine [tHcy], high sensitivity C-reactive protein [hs-CRP] and glycated haemoglobin [HbA1c]) among patients with type 2 diabetes. Settings and Design: Two hundred and forty participants subdivided into Group 1 (T2DM only), Group 2 (T2DM diagnosed with HTN) and Group 3 (controls) were enrolled in a cross-sectional pattern. Subjects and Methods: A structured questionnaire was used to obtain information on self-reported family history. Biochemical parameters were assayed using standard laboratory procedures. Statistical Analysis Used: SPSS version 20.0 was used for statistical analysis with significance at P ≤ 0.05. Results: Group 1: Family history of type 2 diabetes (FHD) (HbA1c, P < 0.001, fasting plasma glucose [FPG], P = 0.005, triglycerides [TG], P = 0.049), family history of HTN (FHTN) (HbA1c, P < 0.001, FPG P = 0.005), family history of obesity (FHO) (HbA1c, P < 0.001, high-density lipoprotein cholesterol [HDL-C], P = 0.049). Group 2: FHD (tHcy, P = 0.021, HDL-C, P = 0.026), FHTN (tHcy, P = 0.035), FHO (HbA1c, P = 0.003, FPG, P = 0.001, TC, P < 0.001, TG, P = 0.019, LDL-C, P = 0.001). Group 3: FHD (tHcy, P = 0.004, HDL-C, P = 0.035), FHTN (FPG, P < 0.001, tHcy P = 0.010, TC, P = 0.037, TG, P = 0.003), FHO (hs-CRP, P < 0.001, HDL-C, P = 0.007, TG P = 0.001, LDL-C P = 0.019). Conclusions: Self-reported positive family history may provide insights into the biochemical and metabolic profile of patients with type 2 diabetes.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1131    
    Printed104    
    Emailed0    
    PDF Downloaded108    
    Comments [Add]    

Recommend this journal